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LANL: Neutron Crystallography Aids Drug Design

on October 9, 2012 - 3:38pm

The Protein Crystallography Station at the Los Alamos Neutron Science Center, where groundbreaking work in new drug-design methods is underway using neutron diffraction techniques. Courtesy/LANL

LANL News:

  • Precisely tailored pharmaceuticals could reduce medical side effects

Researchers at Los Alamos National Laboratory have used neutron crystallography for the first time to determine the structure of a clinical drug in complex with its human target enzyme.

Seeing the detailed structure of the bonded components provides insights into developing more effective drugs with fewer side effects

SFI Seminar: Energy Tradeoffs Between Metabolism, Growth, and Longevity

on October 9, 2012 - 7:52am

SFI News:

The Santa Fe Institute presents "Energy Tradeoffs between Metabolism, Growth, and Longevity" at 12:15 p.m. Thursday Oct. 11 in the Medium Conference Room.

Chen Ho of the Department of Biological Sciences, Missouri University of Science and Technology is conducting the seminar.

Abstract: Diet restriction (DR) and genetic interference (GI) with growth hormone function lead to smaller adult body mass and extended lifespan in mammals, suggesting tradeoffs between growth and longevity.

Despite a rich body of empirical data, still largely missing is a theoretical framework that

SFI Seminar: Fault-Tolerant Memory and Computation in the Presence of Adversarial Noise

on October 6, 2012 - 10:09am

SFI News:

Aram Harrow of the University of Washington will present Fault-Tolerant Memory and Computation in the Presence of Adversarial Noise at 12:15 p.m. Wednesday, Oct. 10 in the Medium Conference Room at the Santa Fe Institute.

Abstract: Theoretical and practical work on fault-tolerant computation has shown that it is possible to compute reliably in the presence of a sufficiently small constant rate of random noise.

In this work, we consider for the first time the case of adversarial noise; i.e.

NNMC Foundation Honors LANL's Richard Marquez

on October 5, 2012 - 12:25pm

LANL News:

Los Alamos National Laboratory Executive Director Richard Marquez is the namesake for a new leadership and service award at Northern New Mexico College (NNMC) in Española.

“I am honored and humbled by this recognition from Northern New Mexico College,” Marquez said. “I have been fortunate with regard to my education and career with opportunities and mentors. I believe in paying it forward and am optimistic that this award will shed light on all of the other people who donate time and resources to making Northern New Mexico a better place.”

The creation of the Richard Marquez

SFI Colloquium: Computability, Gödel's Incompleteness Theorem and an Inherent Limit on the Predictability of Evolution

on October 5, 2012 - 7:08am

SFI Colloquium

Troy Day, Professor and Canada Research Chair, Mathematical Biology, Queens University will present "Computability, Gödel's Incompleteness Theorem, and an Inherent Limit on the Predictability of Evolution" at 3:30 p.m., Tuesday, Oct 9 in the Noyce Conference Room at the Santa Fe Institute.

Abstract: I will briefly review a main way in which mathematical modeling has been used to understand and predict evolutionary change.

I will then highlight an important shortcoming of such approaches and consider an alternative that attempts to overcome the problem.

This alternative

Evolutionary Theory, Web-Search Technology Combine for DNA Analysis

on October 4, 2012 - 11:18am

From left, Los Alamos scientists Joel Berendzen, Ben McMahon, Mira Dimitrijevic, Nick Hengartner and Judith Cohn. Courtesy LANL

LANL News:

  • Bioinformatics breakthrough has clinical & environmental applications

New software from Los Alamos National Laboratory called Sequedex uses evolutionary theory to swiftly identify short “reads” of DNA, calling out the specific organisms from which the DNA came and their likely activity.

“Sequedex makes it possible for a researcher to analyze data hot off a DNA sequencer using a laptop,” said Joel Berendzen, a scientist on the project.

LANL Shatters Records in Year One Shipping Effort

on October 4, 2012 - 6:41am

Los Alamos National Laboratory set a record for transuranic waste shipments from the Laboratory to permanent disposal facilities, sending nearly 60 more shipments than originally planned. Courtesy/LANL

LANL News:

  • Volume, Number of Shipments Surpass Goals

In the first year of an effort to accelerate shipments of transuranic (TRU) waste to the Waste Isolation Pilot Plant (WIPP), Los Alamos National Laboratory shattered its own record with 59 more shipments than planned, and became one of the largest shippers of this type of nuclear waste in the country.

“Our goal this fiscal year was to